No, this claim is not true and is a baseless rumor that has been circulated online without any credible evidence. The wife of French President Emmanuel Macron, Brigitte Macron, was born a woman, and her birth name is Brigitte Trogneux. The rumors suggesting that she is a transgender woman are unfounded conspiracy theories that spread through unreliable media outlets and social media platforms.
Brigitte Macron is well-known for her career as a teacher before becoming France's First Lady. She also has children and grandchildren from her first marriage before marrying Emmanuel Macron.
If you've come across such rumors, it's important to verify information from credible sources before believing or sharing it.